Mustafa Kadhim Al-saeedi
Supervisor Name: Dr. Nagam S. Turkey Al-Awadie
A newly developed analytical method characterized by its speed and sensitivity for the determination of mefenamic acid (MFA) in pure and pharmaceutical preparation via turbidimetric measurement (0-180o ) by Ayah 6SX1-ST-2D Solar cell CFI Analyser. The method was based on the reaction ofCe(IV)Sulfate with mefenamic acid in aqueous medium to form bluish greencolor precipitate for the ion-pair complex. Turbidity was measured via the reflection of incident light that collides on the surface precipitated particles at 0-180o . Chemical and physical parameters were studied and optimized. The calibration graph was linear in the range of 0.3-7 mMol.L-1 , with correlation coefficient r = 0.9954. The limit ofdetection7.35 µg/sample from the step wise dilution for the minimum concentration in the linear dynamic ranged of the calibration graph with RSD% lower than 0.2% for 1,5 mMol.L-1 ( n=6,10 respectively ) concentration of mefenamic acid. The method was successfully applied to the determination of mefenamic acid in four pharmaceutical drugs. A comparison was made between the newly developed method analysis with the classical method in addition to between four different pharmaceutical
preparations (UV- Vis spectrophotometry at wave length 465nm) using the standard addition method via the use of t-test. It was noticed that there was no significant difference between two methods at 95 % confidence level & no significant difference for drugs (Ponstidin - SDI- Iraq and Ponamec-Mvc – India) and significant difference for drugs (piostan- pioner- Iraq and ponstan Pfizer-USA).