Sameran, A. Khalaf
Supervisor Name : Dr. Suaad, M. H. Al-Majidi
This research of some new different heterocyclic derivative of isatin compound. New 1,2,3,4-tetrazoline, 1,2,3-triazol and 1,2,3-triazoline derivatives of isatin which were prepared by condensation isatin with 2-amino pyridine in presence of glacial acetic acid and absolute ethanol as solvent to obtained Schiff bases of isatin 3-(imino pyridine)-1H-indole-2-one(1). The product was treated with sodium hydrite in DMF at 0°C to give asusepension of the sodium salt of isatin derivative and subsequent reaction with chloro acetyl chloride to obtain, 1-(α-chloroacetyl-)-3-(pyridine -2-yl imino) – indole -2-one (2). Whene reaction compound (2) with sodium azide to yield 1-(α- azido acetyl )-3-(pyridine-2-ylimino)-indole-2-one (3).The condensation reaction of substituted primary aromatic amine with different aromatic aldehyde in absolute ethanol give Schiff bases (4-10). Compound (3) react by two ways. The first with Schiff bases compound to obtain 1,2,3,4-tetrazoline derivatives (11-17) while the second way entered in 1,3-dipolar cyclo addition reaction with some of α-β-unsaturated carbonyl compounds to obtain derivatives of 1,2,3-triazoline (18-24) and triazole (25-27) respectively. Newly synthesized compounds were identified by spectral methods. (FTIR, 1H-NMR, 13C-NMR) and measurement of some of its physical properties and also some specific reaction. Furthermore the effects of the synthesized compounds were studied on some strains of bacteria and yeast.